Kullback–Leibler divergence for detection of rare haplotype common disease association
نویسندگان
چکیده
منابع مشابه
FamLBL: detecting rare haplotype disease association based on common SNPs using case-parent triads
MOTIVATION In recent years, there has been an increasing interest in using common single-nucleotide polymorphisms (SNPs) amassed in genome-wide association studies to investigate rare haplotype effects on complex diseases. Evidence has suggested that rare haplotypes may tag rare causal single-nucleotide variants, making SNP-based rare haplotype analysis not only cost effective, but also more va...
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ژورنال
عنوان ژورنال: European Journal of Human Genetics
سال: 2015
ISSN: 1018-4813,1476-5438
DOI: 10.1038/ejhg.2015.25